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Standard Practice for Assessing the Comparative Efficacy of Products Used for the Decontamination of Chemical Warfare Agents (CWAs) on Skin
Automatische name übersetzung:
Standard Praxis zur Beurteilung der vergleichenden Wirksamkeit von Produkten für die Dekontamination von chemischen Kampfstoffen ( CWA ) auf der Haut
NORM herausgegeben am 15.6.2015
Bezeichnung normen: ASTM E3002-15
Anmerkung: UNGÜLTIG
Ausgabedatum normen: 15.6.2015
SKU: NS-609284
Zahl der Seiten: 5
Gewicht ca.: 15 g (0.03 Pfund)
Land: Amerikanische technische Norm
Kategorie: Technische Normen ASTM
Keywords:
acetylcholinesterase, Chemical Warfare Agents (CWAs), decontamination and neutralization, GA Tabun, GB Sarin, GD Soman, GF Cyclohexyl Sarin, HD Mustard, in-vitro, in-vivo, LD50, nerve agents, neutralization, protective ratio, organophosphate (OP), skin, VX Nerve Agent,, ICS Number Code 11.100.99 (Other standards related to laboratory medicine),95.040 (Military engineering)
Significance and Use |
4.1 This practice specifies an 4.2 CWA skin decontaminants will have different modes of action including absorption, adsorption, removal, chemical neutralization or some combination of the above. There is, therefore, no single representative in-vitro method for validation of decontamination efficacy of products for skin decontamination. For example, measuring the presence of a radiolabelled chemical warfare agent after chemical neutralization, may give a false positive results. It has been shown that if the agent has been chemically neutralized, the radiolabel may still be present in a non-toxic molecule. In addition, some chemical neutralization methods may break down the original agent, but the breakdown product is highly toxic. In the case of VX, hydrolysis produces a highly toxic product, EA2192 (S-(2-diisopropylaminoethyl) methylphosphonothioic acid 4.3 This standard practice is of significance in that efficacy is thoroughly evaluated to the extent possible to represent use on human skin. In-vivo studies have demonstrated that simple chemical monitoring for disappearance of the chemical agent may not be sufficient to measure decontamination and neutralization effectiveness. A standard practice is needed for determining actual decontamination and neutralization by measuring the decrease in mortality or lesion size caused by the agent. |
1. Scope |
1.1 This practice establishes an 1.2 This practice provides a quantitative efficacy comparison of different skin decontamination products. 1.3 To minimize the number of animals used, this 1.4 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.5 This standard does not purport to address all of the safety concerns, if any, associated with the use of decontamination products or CWAs. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use. |
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